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New Dermamelan: The World-Recognized Depigmenting Agent

New Dermamelan: The World-Recognized Depigmenting Agent

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With over 30 years of collaboration with the healthcare industry, Mesoestetic is recognized for the development of innovative treatments designed to combat aesthetic problems. In particular hyperpigmented spots. It is a world reference in the treatment of hyperpigmentation. And the New Dermamelan is the cause of this fame.

In this post, we will explain what hyperpigmented spots are, how innovative the New Dermamelan is, and the effectiveness of the treatment. Find out if this procedure is the right one to treat your spots!

The Hyperpigmented Blemishes

Hyperpigmented spots are mostly of melanic origin. That is, they are caused by a high production of melanin. Within this category, the main types of skin spots are melasma, spots of inflammatory origin (HPI), sunspots or senile lentigines, and ephelides. Considering the various types of spots, it is essential to differentiate between them before the start of any depigmentation treatment.

That being said, spots can appear due to numerous triggering factors, the most important being unprotected sun exposure. But there are also other factors, such as genetic predisposition, inflammatory processes, hormonal changes, some photosensitizing drugs such as oral contraceptives or certain anti-inflammatory drugs, antibiotics, among others.

The stains of melanic origin are treated through depigmentation processes. And Mesoestetic is a specialist in depigmentation!

The New Dermamelan

New Dermamelan

Dermamelan is a depigmenting anti-spot treatment, leader in the medical aesthetic industry, due to its enormous effectiveness in correcting and controlling any type of spots of melanic origin. With several years of experience, it has now been reformulated. After 5 years of research, Mesoestetic has launched an innovative formula that increases the depigmenting action of Dermamelan.

The big difference in this new formula?! It significantly inhibits the production of more melanin!

Dermamelan offers a double action: it eliminates cutaneous hyperpigmentations, and at the same time it regulates the overproduction of melanin, thereby inhibiting and controlling the reappearance of new spots. And this is what makes this treatment unique. In other words, it not only treats existing spots but also exerts a significant suppressive action on melanin production, which leads to the prevention of the appearance of new spots.

Inflammation, vascularization, and hormonal activation

The new Dermamelan also focuses on the processes of inflammation, vascularization, and hormonal activation. But how important are these processes in the treatment of spots?! The truth is that these processes lead to the activation of melanogenesis. That is the stimulation of melanin production.

Recent scientific studies relate these three processes to hyperpigmentation. If on the one hand inflammation is directly related to the stimulation of melanin production, on the other, an increase in angiogenesis (formation of new blood vessels) has been found in melasma. Therefore, we can conclude that there is a connection between increased vascularity and melanogenesis (melanin formation). Finally, the hormonal component. And this is probably the most evident and well-known element in the activation of melanogenesis: hormonal changes.

Before and after


Before and after

How does it work?

The most recent medical-scientific advances in the field of hyperpigmentation have allowed the identification of new molecular targets responsible for the pathology. Therefore, Dermamelan has been specifically formulated to act effectively and in a complementary manner on the main key aims of the skin hyperpigmentation process. Thus, it offers a double corrective and regulatory action, making it a unique treatment to eliminate existing spots and prevent their reappearance.

  • Regulatory Action 

Regarding tissue structures, it exerts a protective action against destructuring of the dermo-epidermal barrier, thus preventing the formation of dermal melasma.

Moreover, it inhibits the main molecular mechanisms, triggers of melanocyte overstimulation, such as inflammation, hormonal and vascular components. Typical of the most resistant hyperpigmentations!

At the same time, it controls the different pigmentation mechanisms by reducing melanin synthesis, and by further reducing the melanocyte-keratinocyte transfer. Thus offering an intercellular action.

  • Corrective Action 

It is particularly interesting because it acts on visible blemishes by accelerating the cell renewal process while eliminating the melanin deposits accumulated in the corneal layer.

Who should use it?

Dermamelan is indicated for skins with resistant and persistent hyperpigmented spots. Which do not usually respond to depigmenting treatments, even though they are intensive, such as Cosmelan. Note that Cosmelan is the first-line depigmenting treatment, where the process of elimination of the epidermal spot reaches 95% effectiveness!

The dermamelan treatment is then indicated for situations of:

  • Melasma or Chloasma
  • Post-inflammatory Hyperpigmentation
  • Solar and senile lentigines 
  • Ephelides (“freckles”)

The New Dermamelan vs The Old

Old presentation vs the new

Those who were already fans of the Dermamelan formula may ask why mess with a winning formula whose effectiveness was already recognized worldwide?! In short: the comfort of the patient!  The truth is that to achieve the unbeatable results of the Dermamelan treatment, the patient was required to follow a very specific care routine. In particular, the first exposure to the Dermamelan mask could take up to 12 hours. In addition, the total treatment could take 6 months to 12 months. And the frequency of application in the initial phase was 3x per day. In other words, it was a very demanding treatment.

The new dermamelan, in addition to a more effective formula, is also more comfortable for the patient:

  • Exposure time: 4 hours. New developments have allowed a significant reduction in the exposure time during the consultation phase, reducing it to 4 total hours regardless of phototype (previously it was 8-12 hours). This is due to the greater potency of the actives and the delivery technology.
  • Total treatment time: 4 months. The at-home protocol is also reduced thanks to the improved efficacy of the home formula (previously it was 6 months). The result is also an improvement in patient comfort thanks to a simpler protocol that is compatible with the patient’s life.
  • Daily application frequency: 2 times. The old method was 3 times, which required a beauty routine in the middle of the day. This was inconvenient for patients.
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