Avène Cleanance Comedomed Intensive Serum 30ml
Avène Cleanance Comedomed Intensive Serum is a highly concentrated serum designed for blemish-prone skin that needs targeted care for imperfections, uneven texture and residual red or brown marks.
Suitable for adults and teenagers from 12 years old, this intensive formula contains 30% dermatological active ingredients. It combines Comedoclastin™, glycolic acid, ascorbyl glucoside and bakuchiol to target several concerns at once: excess sebum, blemishes, uneven skin texture, visible pores and post-acne marks.
Avène developed the formula with an approach inspired by laser technology, aiming to provide precise, intensive care without the need for an in-clinic procedure.
The lightweight fluid absorbs quickly and leaves a non-greasy, non-sticky finish. It contains no added fragrance.
What is Cleanance Comedomed Intensive Serum used for?
This intensive serum for acne-prone skin addresses both active imperfections and the marks they can leave behind.
It helps to:
- Reduce the appearance of blemishes.
- Control excess sebum and shine.
- Refine the appearance of skin texture.
- Smooth the skin’s surface.
- Reduce the appearance of red and brown post-acne marks.
- Improve the appearance of uneven skin tone.
- Reduce the appearance of pores.
- Support a more mattified complexion.
- Provide hydration while treating imperfections.
The formula offers a multi-targeted approach, making it particularly useful when acne-prone skin presents several concerns at the same time.
30% dermatological active ingredients
Avène concentrates 30% active ingredients in this serum, with three key components working together.
25% Comedoclastin™
Comedoclastin™ comes from milk thistle and represents one of the main technologies in the Cleanance range. It acts at the origin of blemish formation by helping regulate sebum production and reducing the formation of microcomedones.
By addressing the processes that contribute to new imperfections, Comedoclastin™ helps reduce the appearance of existing blemishes while supporting a clearer-looking complexion.
3% Glycolic Acid
Glycolic acid is an alpha-hydroxy acid (AHA) with exfoliating and keratolytic properties. It helps remove dead skin cells from the skin’s surface and encourages a smoother-looking texture.
In this formula, glycolic acid helps refine skin texture, smooth imperfections and improve the appearance of uneven tone.
Because glycolic acid can increase skin sensitivity to the sun, daily broad-spectrum sunscreen is particularly important when using this serum.
2% Ascorbyl Glucoside and Bakuchiol
The formula combines ascorbyl glucoside, a vitamin C derivative, with bakuchiol in a pro-collagen cocktail.
Together, these ingredients help support a more densified and smoother-looking complexion while complementing the serum’s action on texture and post-acne marks.
A serum inspired by laser precision
The phrase “laser precision” describes the concept behind the product rather than an actual laser treatment. Avène developed the formula with inspiration from technologies used to target visible skin imperfections.
The serum therefore combines several complementary actions in one product: it helps reduce blemishes, exfoliate the surface, refine texture and improve the appearance of residual marks.
This makes it particularly interesting for customers who want a more intensive step than a standard moisturiser or blemish-control product.
Visible results
Avène reports several results from consumer and instrumental testing.
After 28 days of twice-daily use, 70 participants perceived two times fewer imperfections and red or brown residual marks. In another consumer-use test involving 132 participants, the brand reported visible results from the first use.
Instrumental testing also showed 24-hour hydration after application.
These results come from specific manufacturer studies and should not be interpreted as a guarantee of identical results for every skin type.
How to use Avène Cleanance Comedomed Intensive Serum
Apply the serum twice a day, morning and evening, after cleansing the skin with a suitable Cleanance cleanser.
Morning
- Cleanse the face with a gentle Cleanance cleanser.
- Apply a small amount of Cleanance Comedomed Intensive Serum.
- Allow the serum to absorb.
- Follow with a suitable moisturiser if needed.
- Finish with a broad-spectrum SPF50+ sunscreen.
Evening
- Cleanse the face gently.
- Apply the serum evenly over the affected areas or the entire face, according to your routine.
- Follow with a suitable moisturiser if your skin needs additional comfort.
Because the formula contains glycolic acid, introduce other exfoliating acids or potentially irritating active ingredients carefully. Avoid combining several intensive exfoliating products unless a skincare professional recommends this approach.
Why is SPF important when using this serum?
Glycolic acid exfoliates the skin and can increase sensitivity to sunlight. At the same time, post-acne marks can become more noticeable with UV exposure.
For this reason, daily SPF50+ protection forms an important part of a routine that includes Cleanance Comedomed Intensive Serum.
A tinted or non-tinted sunscreen designed for oily, blemish-prone skin can provide convenient daily protection without making the complexion feel excessively heavy.
Who is this serum suitable for?
Avène Cleanance Comedomed Intensive Serum suits:
- Teenagers from 12 years old.
- Adults.
- Oily and blemish-prone skin.
- Skin with recurring imperfections.
- Skin with visible pores.
- Uneven skin texture.
- Skin with red or brown post-acne marks.
- Complexions affected by excess shine.
If your skin feels very sensitive, irritated or compromised, introduce the serum gradually and seek professional advice if necessary. The formula contains glycolic acid and is intended as an intensive treatment for blemish-prone skin.
Why choose Avène Cleanance Comedomed Intensive Serum?
Avène Cleanance Comedomed Intensive Serum combines several targeted dermatological actives in one lightweight formula. Its 30% active-ingredient concentration brings together Comedoclastin™, glycolic acid, ascorbyl glucoside and bakuchiol to address blemishes, excess sebum, uneven texture and post-acne marks.
The result is a comprehensive approach to smoother, more refined and more even-looking skin, with a lightweight finish that suits oily and blemish-prone complexions.
For a complete routine, pair the serum with a gentle Cleanance cleanser, a suitable moisturiser and daily SPF50+ protection.
If you are unsure whether this intensive serum suits your skin, how to introduce it into your existing acne routine, or which Cleanance products you can safely combine with it, please use the Q&A section on the product page. Our team will be happy to help you choose the most appropriate routine.






















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